Dexamethasone improves the efficacy of granisetron in the first 24 h following high-dose cisplatin chemotherapy

  title={Dexamethasone improves the efficacy of granisetron in the first 24 h following high-dose cisplatin chemotherapy},
  author={Jean Latreille M.D.C.M. and Dave Stewart and Francis Laberge and Paul Hoskins and James Rusthoven and Elissa McMurtrie and David Warr and Louise Yelle and David Walde and Frances Shepherd and Harbhajan Dhaliwal and Brian P Findlay and David Mee and Dianne Johnston},
  journal={Supportive Care in Cancer},
The object of the study was to determine whether dexamethasone improved the efficacy of the serotonin receptor (5-HT3) antagonist granisetron in controlling acute (within 24 h) emesis in cancer patients receiving high-dose cisplatin chemotherapy and to ascertain whether continuation of granisetron after 24 h reduces the occurrence of delayed emesis. This randomised, double-blind, multicentre, three-arm study was conducted at 21 medical centres. A group of 292 nausea- and emcsis-free patients… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
13 Extracted Citations
12 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 13 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 12 references

A randomized, double-blind comparison of granisetron with high-dose meto- clopramide, dexamethasone and di- phenhydramine for cisplatin-induced emesis

  • D Warr, A Willan, +10 authors D Johnston
  • Eur J Cancer
  • 1993
3 Excerpts

A comparison of two dose levels of granisetron in patients receiving high dose cisplatin . The Granisetron Study Group

  • Sullivan, MJ Leyden, R Bell
  • Eur J Cancer
  • 1990

The management of che- motherapy-induced nausea and vom- iting

  • R JGralla, LB Tyson, MG Kris, RA Clark
  • Med Clin North Am 71:289-30i
  • 1987
1 Excerpt

Similar Papers

Loading similar papers…