Dexamethasone enhances vitamin D-24-hydroxylase expression in osteoblastic (UMR-106) and renal (LLC-PK1) cells treated with 1α,25-dihydroxyvitamin D3

@article{Kurahashi2002DexamethasoneEV,
  title={Dexamethasone enhances vitamin D-24-hydroxylase expression in osteoblastic (UMR-106) and renal (LLC-PK1) cells treated with 1α,25-dihydroxyvitamin D3},
  author={Izuru Kurahashi and Ayako Matsunuma and Tetsuya Kawane and Masatoshi Abe and Dr. Noboru Horiuchi},
  journal={Endocrine},
  year={2002},
  volume={17},
  pages={109-118}
}
Chronic glucocorticoid therapy causes rapid bone loss and clinical osteoporosis. We previously found that dexamethasone, a potent glucocorticoid, increased renal expression of vitamin D-24-hydroxylase, which degrades such vitamin D metabolites as 25-hydroxyvitamin D3 and 1α,25-dihydroxyvitamin D3 (1,25[OH]2D3). We therefore investigated the mechanisms of this increase in UMR-106 osteoblast-like cells and LLC-PK1 kidney cells. To induce 24-hydroxylase expression, 1,25(OH)2D3 (10−7 M) and… CONTINUE READING

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Dexamethasone Increases 24-Hydroxylase

K. S. Chen, H. F. DeLuca
Biochim. Biophys. Acta 1263, • 1995
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