Dexamethasone enhances agonist induction of tissue factor in monocytes but not in endothelial cells.

@article{Bottles1993DexamethasoneEA,
  title={Dexamethasone enhances agonist induction of tissue factor in monocytes but not in endothelial cells.},
  author={K D Bottles and James H Morrissey},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  year={1993},
  volume={4 3},
  pages={405-14}
}
Stimulation of monocytic cells by inflammatory agents such as bacterial lipopolysaccharide or tumour necrosis factor-alpha leads to the rapid and transient expression of tissue factor, the major cellular initiator of the extrinsic coagulation cascade in both haemostasis and tissue inflammation. In this study we investigated whether the synthetic anti-inflammatory glucocorticoid, dexamethasone, would inhibit agonist induction of tissue factor expression in both monocytes and endothelial cells… CONTINUE READING