Dexamethasone augmentation in treatment-resistant depression.

  title={Dexamethasone augmentation in treatment-resistant depression.},
  author={Timothy G Dinan and Ena Lavelle and JohnA. Cooney and F. C. E. Burnett and Lucinda Scott and Atreya Dash and J Thakore and Caterina Berti},
  journal={Acta psychiatrica Scandinavica},
  volume={95 1},
A total of 10 patients who fulfilled DSM-III-R criteria for major depression were recruited to the study, each of whom had failed to respond to a 6-week course of treatment with either sertraline or fluoxetine. Each subject had baseline serum cortisol measurements together with a Hamilton depression (HAMD) score. All patients were started on dexamethasone (3 mg daily) for 4 days, while remaining on their antidepressant treatment. Further Hamilton ratings were made on days 5 and 21. Six patients… CONTINUE READING

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