Dexamethasone and recombinant human activated protein C improve myocardial function and efficiency during experimental septic shock.

Corticosteroids have been shown to reduce short-term mortality during septic shock and therefore recommended in the most severe patients as adjuvant therapy. Until recently, recombinant human activated protein C (APC) was also considered in the management of more severe cases. As myocardial depression has long been recognized as a manifestation of organ… CONTINUE READING