Dexamethasone and interleukins modulate apoptosis of murine thymocytes and peripheral T-lymphocytes.

@article{Migliorati1994DexamethasoneAI,
  title={Dexamethasone and interleukins modulate apoptosis of murine thymocytes and peripheral T-lymphocytes.},
  author={Graziella Migliorati and Ildo Nicoletti and Giuseppe Nocentini and Maria Cristina Pagliacci and Carlo Riccardi},
  journal={Pharmacological research},
  year={1994},
  volume={30 1},
  pages={43-52}
}
Glucocorticoid hormones (GCH) induce apoptotic cell death in immature thymocytes through an active process, characterized by extensive DNA fragmentation into oligonucleosomal subunits. This requires macromolecular synthesis and is inhibited by interleukins (ILs). We performed experiments to analyse the possible effect of GCH on more differentiated lymphocytes, i.e. peripheral (from lymph nodes and spleen) T-lymphocytes. The results show that in vitro dexamethasone (DEX) induces DNA… CONTINUE READING

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Apoptosis Genes

  • James W. Wilson Catherine Booth Christopher S. Potten
  • Springer US
  • 1998

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