Dexamethasone and hypoxia upregulate CXCR4 expression in myeloma cells.

  title={Dexamethasone and hypoxia upregulate CXCR4 expression in myeloma cells.},
  author={Seong-Woo Kim and H Kim and Hyo Jin Lee and Hwan-Jung Yun and Samyong Kim and Deog-Yeon Jo},
  journal={Leukemia & lymphoma},
  volume={50 7},
We investigated the modulation of CXCR4 expression by cytokines, dexamethasone, and hypoxia in myeloma cells in vitro. Tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) enhanced CXCR4 expression in RPMI8226 cells. In the myeloma cell lines examined and primary bone marrow (BM) CD138+ cells, dexamethasone enhanced CXCR4 expression both in the cytoplasm and on the cell surface, while downregulating SDF-1 expression… CONTINUE READING