Dexamethasone and colchicine reduce inflammation and delayed oedema following experimental brain contusion

@article{Holmin1996DexamethasoneAC,
  title={Dexamethasone and colchicine reduce inflammation and delayed oedema following experimental brain contusion},
  author={Staffan Holmin and Tiit Mathiesen},
  journal={Acta Neurochirurgica},
  year={1996},
  volume={138},
  pages={418-424}
}
The effect of anti-inflammatory treatment on monocyte/macrophage infiltration, major histocompatibility complex molecules (MHC) class II expression and delayed oedema following experimental brain contusion was studied by immunohistochemistry and tissue-specific gravity measurement in 44 rats. Colchicine, chloroquine and dexamethasone administered once daily for five days after the trauma reduced inflammation and oedema. The difference was statistically significant with colchicine and… CONTINUE READING