Dexamethasone and High-Dose Methotrexate Improve Outcome for Children and Young Adults With High-Risk B-Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group Study AALL0232.

@article{Larsen2016DexamethasoneAH,
  title={Dexamethasone and High-Dose Methotrexate Improve Outcome for Children and Young Adults With High-Risk B-Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group Study AALL0232.},
  author={Eric C. Larsen and Meenakshi Devidas and Si Chen and Wanda L Salzer and Elizabeth A. Raetz and Mignon L Loh and Leonard A. Mattano and Catherine M. Cole and Alisa Eicher and Maureen Haugan and Mark Sorenson and Nyla A. Heerema and Andrew A Carroll and Julie M. Gastier-Foster and Michael J. Borowitz and Brent L Wood and Cheryl L. Willman and Naomi Joan Winick and Stephen P Hunger and William L Carroll},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2016},
  volume={34 20},
  pages={
          2380-8
        }
}
PURPOSE Survival for children and young adults with high-risk B-acute lymphoblastic leukemia has improved significantly, but 20% to 25% of patients are not cured. Children's Oncology Group study AALL0232 tested two interventions to improve survival. PATIENTS AND METHODS Between January 2004 and January 2011, AALL0232 enrolled 3,154 participants 1 to 30 years old with newly diagnosed high-risk B-acute lymphoblastic leukemia. By using a 2 × 2 factorial design, 2,914 participants were randomly… CONTINUE READING
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