Dexamethasone acetate encapsulation into Trojan particles.

  title={Dexamethasone acetate encapsulation into Trojan particles.},
  author={Carolina G{\'o}mez-Gaete and Elias Fattal and Lidia Martins da Silva and Madeleine Besnard and Nicolas Tsapis},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={128 1},
We have combined the therapeutic potential of nanoparticles systems with the ease of manipulation of microparticles by developing a hybrid vector named Trojan particles. We aim to use this new delivery vehicle for intravitreal administration of dexamethasone. Initialy, dexamethasone acetate (DXA) encapsulation into biodegradable poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles was optimized. Then, Trojan particles were formulated by spray drying 1,2-Dipalmitoyl-sn-Glycero-3-Phosphocholine… CONTINUE READING
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