Dexamethasone Stimulates Insulin Receptor Synthesis in Cultured Rat Hepatocytes

@inproceedings{Arthur2001DexamethasoneSI,
  title={Dexamethasone Stimulates Insulin Receptor Synthesis in Cultured Rat Hepatocytes},
  author={Arthur and SalhanickS and Michael and Krupps and John M. AmatrudalI},
  year={2001}
}
  • Arthur, SalhanickS, +2 authors John M. AmatrudalI
  • Published 2001
The ability of the glucocorticoid dexamethasone to modulate the insulin receptor was examined directly in primary cultures of hepatocytes prepared from adult male rats. Hepatocytes were cultured in a defined medium in the presence and absence of dexamethasone, 0.1 MM. The exposure of hepatocytes to dexamethasone resulted in a time-dependent (steady state by 32 h) increase in insulin binding in both intact hepatocytes and Triton X-100-soluble extracts (total insulin receptor content). The… CONTINUE READING