Dexamethasone Induces Lipocalin‐Type Prostaglandin D Synthase Gene Expression in Mouse Neuronal Cells

@article{GarcaFernndez2000DexamethasoneIL,
  title={Dexamethasone Induces Lipocalin‐Type Prostaglandin D Synthase Gene Expression in Mouse Neuronal Cells},
  author={L. Garc{\'i}a-Fern{\'a}ndez and M. A. Iñiguez and N. Eguchi and M. Fresno and Y. Urade and A. Mu{\~n}oz},
  journal={Journal of Neurochemistry},
  year={2000},
  volume={75}
}
Lipocalin‐type prostaglandin (PG) D synthase (L‐PGDS) is responsible for the production of PGD2, the main PG in the CNS. PGD2 is an endogenous sleep inducer, and it is involved in the control of odor and pain responses and body temperature. In addition, PGD synthase transports lipophilic molecules in the subarachnoid space and CSF. By northern and western assays we show that the synthetic glucocorticoid dexamethasone, an inhibitor of PG production in most tissues, induces L‐PGDS mRNA and… Expand
Lipocalin-type and hematopoietic prostaglandin D synthases as a novel example of functional convergence.
[Functional analyses of lipocalin-type and hematopoietic prostaglandin D synthases].
Prostaglandin-D Synthase
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