Dexamethasone/1alpha-25-dihydroxyvitamin D3-treated dendritic cells suppress colitis in the SCID T-cell transfer model.

@article{Pedersen2009Dexamethasone1alpha25dihydroxyvit,
  title={Dexamethasone/1alpha-25-dihydroxyvitamin D3-treated dendritic cells suppress colitis in the SCID T-cell transfer model.},
  author={Anders Elm Pedersen and Esben Gjerl\off Wedebye Schmidt and Monika Gad and Steen Seier Poulsen and Mogens Helweg Claesson},
  journal={Immunology},
  year={2009},
  volume={127 3},
  pages={354-64}
}
Autoantigen-presenting immunomodulatory dendritic cells (DCs) that are used for adoptive transfer have been shown to be a promising therapy for a number of autoimmune diseases. We have previously demonstrated that enteroantigen-pulsed DCs treated with interleukin-10 (IL-10) can partly protect severe combined immunodeficient (SCID) mice adoptively transferred with CD4+ CD25(-) T cells from the development of wasting disease and colitis. We therefore established an in vitro test that could… CONTINUE READING

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