Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase


OBJECTIVE To find out whether dexamethasone induces an uncoupling of the endothelial nitric oxide synthase (eNOS). METHODS & RESULTS A major cause of eNOS uncoupling is a deficiency of its cofactor tetrahydrobiopterin (BH4). Treatment of human EA.hy 926 endothelial cells with dexamethasone decreased mRNA and protein expression of both BH4-synthesizing… (More)
DOI: 10.11909/j.issn.1671-5411.2015.05.013