Device-based in vitro techniques for mechanical stimulation of vascular cells: a review.

@article{Davis2015DevicebasedIV,
  title={Device-based in vitro techniques for mechanical stimulation of vascular cells: a review.},
  author={Caleb A Davis and Steve Zambrano and Pratima Anumolu and Alicia C B Allen and Leonardo Sonoqui and Michael R. Moreno},
  journal={Journal of biomechanical engineering},
  year={2015},
  volume={137 4},
  pages={040801}
}
The most common cause of death in the developed world is cardiovascular disease. For decades, this has provided a powerful motivation to study the effects of mechanical forces on vascular cells in a controlled setting, since these cells have been implicated in the development of disease. Early efforts in the 1970 s included the first use of a parallel-plate flow system to apply shear stress to endothelial cells (ECs) and the development of uniaxial substrate stretching techniques (Krueger et al… CONTINUE READING