Devic's neuromyelitis optica: a clinicopathological study of 8 patients.

@article{Mandler1993DevicsNO,
  title={Devic's neuromyelitis optica: a clinicopathological study of 8 patients.},
  author={Raul N. Mandler and Larry E. Davis and D. Ross Jeffery and Mario Kornfeld},
  journal={Annals of neurology},
  year={1993},
  volume={34 2},
  pages={162-8}
}
We report the clinical, imaging, and laboratory features of 8 patients with Devic's neuromyelitis optica. All patients had severe myelopathy and optic neuritis. In no patient was the brain, the brainstem, or the cerebellum affected, even after several years of disease. Various immunosuppressive treatments failed to benefit the patients, 5 of whom died. Autopsies of these 5 patients demonstrated a severe necrotizing myelopathy with thickening of blood vessel walls and no lymphocyte infiltrates… CONTINUE READING