Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability

@article{Bakhoum2009DeviantKM,
  title={Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability},
  author={Samuel F. Bakhoum and Giulio Genovese and Duane A Compton},
  journal={Current Biology},
  year={2009},
  volume={19},
  pages={1937-1942}
}
The persistent malattachment of microtubules to chromosomes at kinetochores is a major mechanism of chromosomal instability (CIN) [1, 2]. In normal diploid cells, malattachments arise spontaneously and are efficiently corrected to preserve genomic stability [3]. However, it is unknown whether cancer cells with CIN possess the ability to efficiently correct attachment errors. Here we show that kinetochore microtubule attachments in cancer cells with CIN are inherently more stable than those in… CONTINUE READING

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