Developments in molecular SIMS depth profiling and 3D imaging of biological systems using polyatomic primary ions.

@article{Fletcher2011DevelopmentsIM,
  title={Developments in molecular SIMS depth profiling and 3D imaging of biological systems using polyatomic primary ions.},
  author={John S Fletcher and Nicholas P Lockyer and John C. Vickerman},
  journal={Mass spectrometry reviews},
  year={2011},
  volume={30 1},
  pages={
          142-74
        }
}
In principle mass spectral imaging has enormous potential for discovery applications in biology. The chemical specificity of mass spectrometry combined with spatial analysis capabilities of liquid metal cluster beams and the high yields of polyatomic ion beams should present unprecedented ability to spatially locate molecular chemistry in the 100 nm range. However, although metal cluster ion beams have greatly increased yields in the m/z range up to 1000, they still have to be operated under… CONTINUE READING
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