Developments in metastatic pancreatic cancer: is gemcitabine still the standard?

  title={Developments in metastatic pancreatic cancer: is gemcitabine still the standard?},
  author={Jie-er Ying and Li-ming Zhu and Bi-Xia Liu},
  journal={World journal of gastroenterology},
  volume={18 8},
In the past 15 years, we have seen few therapeutic advances for patients with pancreatic cancer, which is the fourth leading cause of cancer-related death in the United States. Currently, only about 6% of patients with advanced disease respond to standard gemcitabine therapy, and median survival is only about 6 mo. Moreover, phase III trials have shown that adding various cytotoxic and targeted chemotherapeutic agents to gemcitabine has failed to improve overall survival, except in cases in… CONTINUE READING
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