Developments in chemotherapy of breast cancer.

  title={Developments in chemotherapy of breast cancer.},
  author={Gabriel N Hortobagyi},
  volume={88 12 Suppl},
BACKGROUND Breast carcinoma is moderately sensitive to multiple antitumor agents. Cytotoxic combination regimens developed in the 1970s were shown to produce higher response rates and longer durations of response and survival than single-agent therapy. These regimens became the standard of care for the management of metastatic, hormone-refractory breast carcinoma, and more recently, for primary breast carcinoma. Randomized trials also have demonstrated that anthracycline-containing combinations… CONTINUE READING


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