Developments in Nonsteroidal Antiandrogens Targeting the Androgen Receptor

@article{Liu2010DevelopmentsIN,
  title={Developments in Nonsteroidal Antiandrogens Targeting the Androgen Receptor},
  author={Bo Liu and Lei Su and Jingkun Geng and Junjie Liu and Guisen Zhao},
  journal={ChemMedChem},
  year={2010},
  volume={5}
}
The burden of prostate cancer (PCa) in the world is significant; PCa remains the most frequently diagnosed noncutaneous malignancy and remains the second leading cause of cancer-related deaths among men in Western countries. In 2009, approximately 192 280 men were diagnosed with PCa, and 27 360 men were estimated to die from the disease. The risk factor in PCa includes, but is not limited to, race, geography, age and gene rearrangements. Though patients with PCa initially respond to androgen… 

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