Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II

@article{Schoeftner2008DevelopmentallyRT,
  title={Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II},
  author={Stefan Schoeftner and Mar{\'i}a A. Blasco},
  journal={Nature Cell Biology},
  year={2008},
  volume={10},
  pages={228-236}
}
Mammalian telomeres consist of non-coding TTAGGG repeats that are bound by the multi-protein complex 'shelterin', thus protecting chromosome ends from DNA repair mechanisms and degradation. Mammalian telomeric chromatin is enriched for the constitutive heterochromatin marks H3K9me3, H4K20me3 and HP1 (refs 2–7). Similar to pericentric heterochromatin, telomeric heterochromatin is thought to be fundamental for the maintenance of chromosomal integrity. Here, we report that telomeric repeats are… 
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