Developmentally regulated nuclear transport of transcription factors in Drosophila embryos enable the heat shock response.

@article{Wang1998DevelopmentallyRN,
  title={Developmentally regulated nuclear transport of transcription factors in Drosophila embryos enable the heat shock response.},
  author={Z Yan Wang and Susan Lindquist},
  journal={Development},
  year={1998},
  volume={125 23},
  pages={4841-50}
}
Hsp70 is a broadly conserved thermotolerance factor, but inhibits growth at normal temperatures and cannot be induced in early embryos. We report that in Drosophila embryos the temporal and spatial patterns of Hsp70 inducibility were unexpectedly complex, with striking differences between the soma and the germline. In both, regulation occurred at the level of transcription. During the refractory period for Hsp70 induction, HSF (heat-shock transcription factor) exhibited specific DNA-binding… CONTINUE READING

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