Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding.

@article{Moody2001DevelopmentallyRG,
  title={Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding.},
  author={Anne Marie Moody and Daniel Chui and Pedro A. Reche and John J. Priatel and Jamey D Marth and Ellis L. Reinherz},
  journal={Cell},
  year={2001},
  volume={107 4},
  pages={501-12}
}
The functional consequences of glycan structural changes associated with cellular differentiation are ill defined. Herein, we investigate the role of glycan adducts to the O-glycosylated polypeptide stalk tethering the CD8alphabeta coreceptor to the thymocyte surface. We show that immature CD4(+)CD8(+) double-positive thymocytes bind MHCI tetramers more avidly than mature CD8 single-positive thymocytes, and that this differential binding is governed by developmentally programmed O-glycan… CONTINUE READING
40 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…