Developmentally regulated expression of two novel platelet-derived growth factor alpha-receptor transcripts in human teratocarcinoma cells.

@article{Mosselman1994DevelopmentallyRE,
  title={Developmentally regulated expression of two novel platelet-derived growth factor alpha-receptor transcripts in human teratocarcinoma cells.},
  author={Sietse Mosselman and Lena Claesson-Welsh and Johannes S Kamphuis and E J Van zoelen},
  journal={Cancer research},
  year={1994},
  volume={54 1},
  pages={220-5}
}
Two novel platelet-derived growth factor (PDGF) alpha-receptor transcripts of 1.5 kilobases and 5.0 kilobases are expressed in the human teratocarcinoma cell line Tera-2 only while the cells are in an undifferentiated state. After retinoic acid-induced differentiation, expression of these mRNAs is completely shut off and instead, the cells express a single 6.4-kilobase mRNA species which is also expressed in many other cell types. The 1.5-kilobase mRNA initiates within intron 12, contains the… CONTINUE READING

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