Developmentally regulated expression of ceramide in Trypanosoma cruzi.

@article{Bertello1996DevelopmentallyRE,
  title={Developmentally regulated expression of ceramide in Trypanosoma cruzi.},
  author={Laura E. Bertello and Norma W Andrews and Rosa M. de Lederkremer},
  journal={Molecular and biochemical parasitology},
  year={1996},
  volume={79 2},
  pages={143-51}
}
Amastigote forms of T. cruzi express the specific Ssp-4 surface antigen which is progressively shed, by the action of an endogenous phosphatidylinositol-phospholipase C, during their development into epimastigotes (Andrews et al., J. Exp. Med., 167 (1988) 300-314). We show now that the lipid moiety of the anchor of Ssp-4 is a ceramide which was metabolically labelled with [3H]palmitic acid. The lipid could be cleaved by PI-PLC digestion in vitro, and was identified by methanolysis and reverse… CONTINUE READING

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