Developmentally regulated expression of a cell surface class I nuclease in Leishmania mexicana.

@article{Sopwith2002DevelopmentallyRE,
  title={Developmentally regulated expression of a cell surface class I nuclease in Leishmania mexicana.},
  author={Will Sopwith and Alain Debrabant and Mat Yamage and Dennis M. Dwyer and Paul A. Bates},
  journal={International journal for parasitology},
  year={2002},
  volume={32 4},
  pages={
          449-59
        }
}
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28 Citations
Highly Influential Citations
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Background Citations
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28 Citations

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46 References

Molecular Characterization of a Hyperinducible, Surface Membrane-anchored, Class I Nuclease of a Trypanosomatid Parasite*

Results of the nuclear run-on analyses demonstrated that the dramatic up-expression of 3′-NT/NU activity in response to purine starvation of C. luciliae was concomitant with the ∼100-fold elevation in steady-state mRNA specific for this gene.

Isolation and characterization of the gene encoding the surface membrane 3'-nucleotidase/nuclease of Leishmania donovani.

Leishmania donovani: regulated changes in the level of expression of the surface 3'-nucleotidase/nuclease.

An inducible 3'-nucleotidase/nuclease from the trypanosomatid Crithidia luciliae. Purification and characterization.

The immunologically protective P-4 antigen of Leishmania amastigotes. A developmentally regulated single strand-specific nuclease associated with the endoplasmic reticulum.

The purified membrane-associated Leishmania pifanoi amastigote protein P-4 has been shown to induce protective immunity against infection and to elicit preferentially a T helper 1-like response in…

Characterization of developmentally-regulated nucleases in promastigotes and amastigotes of Leishmania mexicana.

    P. Bates
    Biology
    FEMS microbiology letters
  • 1993
The parasitic protozoon Leishmania mexicana was examined for the presence of 3'-nucleotidase/nuclease using substrate SDS-PAGE and the 29/31 kDa form showed a broader, unique substrate specificity in that it was also capable of digesting double-stranded RNA and DNA.

The surface membrane 3'-nucleotidase/nuclease of trypanosomatid protozoa.

Dissection of the Functional Domains of theLeishmania Surface Membrane 3′-Nucleotidase/Nuclease, a Unique Member of the Class I Nuclease Family*

Some of the functional domains of this unique member of the class I nuclease family, the 3′-nucleotidase/nuclease (Ld3′NT/NU), are defined using the fidelity of a homologous expression system.

Phosphomonoesterases of Leishmania mexicana mexicana and other flagellates.

Surface membrane localization of 3'- and 5'-nucleotidase activities in Leishmania donovani promastigotes.