Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome

@article{Plath2004DevelopmentallyRA,
  title={Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome},
  author={Kathrin Plath and Dale J Talbot and Karien M. Hamer and Arie P. Otte and Thomas P. Yang and Rudolf Jaenisch and Barbara Panning},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={167},
  pages={1025 - 1035}
}
Polycomb group (PcG) proteins belonging to the polycomb (Pc) repressive complexes 1 and 2 (PRC1 and PRC2) maintain homeotic gene silencing. In Drosophila, PRC2 methylates histone H3 on lysine 27, and this epigenetic mark facilitates recruitment of PRC1. Mouse PRC2 (mPRC2) has been implicated in X inactivation, as mPRC2 proteins transiently accumulate on the inactive X chromosome (Xi) at the onset of X inactivation to methylate histone H3 lysine 27 (H3-K27). In this study, we demonstrate that… CONTINUE READING
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Dynamic and differential regulation of histone methylation on the inactive X chromosome

  • K. Plath, I.-h. Su, C. C. de la Cruz, J. Fang, A. Tarakhovsky, B. Panning.
  • PNAS. In press.
  • 2005
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