Developmentally controlled expression of immunoglobulin VH genes.

@article{Perlmutter1985DevelopmentallyCE,
  title={Developmentally controlled expression of immunoglobulin VH genes.},
  author={Roger M. Perlmutter and John F Kearney and Sandra P. Chang and Leroy E. Hood},
  journal={Science},
  year={1985},
  volume={227 4694},
  pages={1597-601}
}
Although antibody diversity arises mainly from apparently random combinatorial and somatic mutational mechanisms acting upon a limited number of germline antibody genes, the antibody repertoire develops in an ordered fashion during mammalian ontogeny. A series of early pre-B and B-lymphocyte cell lines were examined to determine whether an ordered rearrangement of gene families of the variable region of immunoglobulin heavy chains (VH) may be the basis for the programmed development of the… CONTINUE READING

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