Developmentally arrested oviduct: a structural and functional defect in mice following prenatal exposure to diethylstilbestrol.

@article{Newbold1983DevelopmentallyAO,
  title={Developmentally arrested oviduct: a structural and functional defect in mice following prenatal exposure to diethylstilbestrol.},
  author={Retha R. Newbold and S J Tyrey and Arthur F. Haney and J A McLachlan},
  journal={Teratology},
  year={1983},
  volume={27 3},
  pages={417-26}
}
To determine the effects of exposure to diethylstilbestrol (DES) on the developing oviduct, timed pregnant CD-1 mice were treated with DES (10-100 micrograms/kg subcutaneous) on days 9-16 of gestation. Prenatal DES-exposed and age-matched control mice were sacrificed from day 16 of gestation to 15 weeks of age and oviductal development was compared. Following prenatal exposure to DES (100 micrograms/kg), the oviduct at all ages examined was uncoiled and shorter, closely adherent to and wrapped… CONTINUE READING