Developmentally Regulated Post-translational Modification of Nucleoplasmin Controls Histone Sequestration and Deposition.

@article{Onikubo2015DevelopmentallyRP,
  title={Developmentally Regulated Post-translational Modification of Nucleoplasmin Controls Histone Sequestration and Deposition.},
  author={Takashi Onikubo and Joshua J. Nicklay and Li Zhao Xing and Christopher Warren and Brandon Anson and Wei-lin Wang and Emmanuel S Burgos and Sophie E Ruff and Jeffrey Shabanowitz and Russell C. H. Cheng and Donald F. Hunt and David Shechter},
  journal={Cell reports},
  year={2015}
}
Nucleoplasmin (Npm) is an abundant histone chaperone in vertebrate oocytes and embryos. During embryogenesis, regulation of Npm histone binding is critical for its function in storing and releasing maternal histones to establish and maintain the zygotic epigenome. Here, we demonstrate that Xenopus laevis Npm post-translational modifications (PTMs) specific to the oocyte and egg promote either histone deposition or sequestration, respectively. Mass spectrometry and Npm phosphomimetic mutations… CONTINUE READING
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