Developmental variability in expression and regulation of inducible nitric oxide synthase in rat intestine.

@article{Morin2001DevelopmentalVI,
  title={Developmental variability in expression and regulation of inducible nitric oxide synthase in rat intestine.},
  author={Melinda J. Morin and Stephanie Karr and Ronald A. Faris and Philip A Gruppuso},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2001},
  volume={281 2},
  pages={G552-9}
}
Inducible nitric oxide synthase (iNOS) may be a key mediator of intestinal injury, which varies with developmental age. One member of the mitogen-activated protein kinase (MAPK) family, p38, is involved in the lipopolysaccharide (LPS)-mediated iNOS induction. The involvement of p38 MAPK in basal and LPS-induced iNOS expression was examined in the rat intestine at two developmental ages. Neonatal (4 days postnatal) and adolescent (15 days postnatal) rats were injected with LPS (5 microg/g ip), a… CONTINUE READING

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