Developmental transformation of the release modality at the calyx of Held synapse.

@article{Fedchyshyn2005DevelopmentalTO,
  title={Developmental transformation of the release modality at the calyx of Held synapse.},
  author={Michael J. Fedchyshyn and L Y Wang},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 16},
  pages={4131-40}
}
Ca(2+) influx through voltage-gated Ca(2+) channels (VGCCs) into nerve terminals triggers vesicular fusion and neurotransmitter release. However, it is unknown whether the coupling between VGCCs and synaptic vesicles (SVs) is developmentally regulated. By paired patch-clamp recordings from the mouse calyx of Held synapse, we show here that injection of a Ca(2+) buffer with slow binding kinetics (EGTA; 10 mm) potently attenuated transmitter release in young terminals [postnatal day 8 (P8)-P12… CONTINUE READING