Developmental toxicity of methanol: Pathogenesis in CD-1 and C57BL/6J mice exposed in whole embryo culture.

Abstract

BACKGROUND Methanol causes axial skeleton and craniofacial defects in both CD-1 and C57BL/6J mice during gastrulation, but C57BL/6J embryos are more severely affected. We evaluated methanol-induced pathogenesis in CD-1 and C57BL/6J embryos exposed during gastrulation in whole embryo culture. METHODS Conceptuses with five to seven somites were exposed to 0… (More)

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@article{Degitz2004DevelopmentalTO, title={Developmental toxicity of methanol: Pathogenesis in CD-1 and C57BL/6J mice exposed in whole embryo culture.}, author={Sigmund J. Degitz and John M. Rogers and Robert Martin Zucker and Edward Sidney Hunter}, journal={Birth defects research. Part A, Clinical and molecular teratology}, year={2004}, volume={70 4}, pages={179-84} }