Developmental toxicity of domoic acid in zebrafish (Danio rerio).

  title={Developmental toxicity of domoic acid in zebrafish (Danio rerio).},
  author={Jessica A. Tiedeken and John S. Ramsdell and Ann F Ramsdell},
  journal={Neurotoxicology and teratology},
  volume={27 5},
Domoic acid (DA) is a rigid analog of the excitatory amino acid glutamate. It is produced by the diatom genus Pseudo-nitzschia and is a potent neurotoxin in both adult and developing animals. We have used zebrafish (Danio rerio) as a model to investigate and characterize the developmental toxicity of DA. Domoic acid was administered by microinjection to fertilized eggs at the 128- to 512-cell stages in concentrations ranging from 0.12 to 17 mg/kg (DA/egg weight). DA reduced hatching success by… CONTINUE READING