Developmental toxicity of copaiba tree (Copaifera reticulata Ducke, Fabaceae) oleoresin in rat.

@article{Sachetti2011DevelopmentalTO,
  title={Developmental toxicity of copaiba tree (Copaifera reticulata Ducke, Fabaceae) oleoresin in rat.},
  author={Camile Giaretta Sachetti and Ros{\^a}ngela Ribeiro de Carvalho and Francisco J R Paumgartten and Osmar Alves Lameira and Eloisa Dutra Caldas},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2011},
  volume={49 5},
  pages={
          1080-5
        }
}
The oleoresin of the copaiba tree (Copaifera sp., Fabaceae) is traditionally used in Brazilian herbal medicine to treat a variety of illnesses and symptoms. This study, conducted according to the OECD Guideline 414, provides data on the developmental toxicity of oleoresin from C. reticulata (COPA-R) in rats. Pregnant Wistar rats (25 per dose group) were treated by gavage with COPA-R (0, 500, 1000 and 1250 mg/kg bw/day) on gestation days (GD) 6-19 and Caesarean sections performed on GD20… CONTINUE READING

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