Developmental toxicity of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). I. Multireplicated dose-response studies in four inbred strains and one outbred stock of mice.

@article{Holson1992DevelopmentalTO,
  title={Developmental toxicity of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). I. Multireplicated dose-response studies in four inbred strains and one outbred stock of mice.},
  author={Joseph F Holson and T B Gaines and Christina J Nelson and J B L{\'a}borde and David W. Gaylor and Daniel M. Sheehan and John Fariselli Young},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1992},
  volume={19 2},
  pages={286-97}
}
A large-scaled multireplicated developmental toxicity study was conducted in various strains/stocks of mice with the herbicide, 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), by gavage on Gestational Days 6 through 14. The most important attributes of the study design were replicated test groups, a minimum of four dose levels per replicate, use of multiple stocks/strains of animals to obtain an estimate of the range in sensitivities due to genotype, complete pathological evaluation of maternal… CONTINUE READING