Developmental toxicity of Citrus aurantium in rats.

@article{Hansen2011DevelopmentalTO,
  title={Developmental toxicity of Citrus aurantium in rats.},
  author={Deborah K. Hansen and Beth Elisa Juliar and Gene E. White and Linda S. Pellicore},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2011},
  volume={92 3},
  pages={
          216-23
        }
}
BACKGROUND Ephedra was commonly used in herbal products marketed for weight loss until safety concerns forced its removal from products. Even before the ban, manufacturers had begun to replace ephedra with other compounds, including Citrus aurantium, or bitter orange. The major component in the bitter orange extract is synephrine which is chemically similar to ephedrine. The purpose of this study was to determine if relatively pure synephrine or synephrine present as a constituent of a bitter… CONTINUE READING
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