Developmental toxicity evaluation of monoisoamyl meso-2,3-dimercaptosuccinate in mice.

  title={Developmental toxicity evaluation of monoisoamyl meso-2,3-dimercaptosuccinate in mice.},
  author={M. A. Bosque and Jos{\'e} Luis Domingo and Jacinto Corbella and M. M. Jones and P. K. Singh},
  journal={Journal of toxicology and environmental health},
  volume={42 4},
Monoisoamyl meso-2,3-dimercaptosuccinate (Mi-ADMS), a new dimercaptosuccinic acid (DMSA) analog with enhanced lipophilic properties, was evaluated for potential developmental toxicity. Intraperitoneal injections of Mi-ADMS were given to female Swiss mice (0, 47.5, 95, and 190 mg/kg) on gestational d 6-15. The maternal clinical status was monitored daily during treatment. At termination (gestational d 18), dams were evaluated for clinical status and gestational outcome. Each live fetus was… 

MiADMSA abrogates chronic copper-induced hepatic and immunological changes in Sprague Dawley Rats.

  • Jayant PatwaS. Flora
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2020

Quercetin Administration During Chelation Therapy Protects Arsenic-Induced Oxidative Stress in Mice

It is concluded that quercetin administration during chelation treatment had some beneficial effects particularly on the protection of inhibited blood ALAD activity and depletion of arsenic level from target organs.

Amelioration of lead-induced hepatotoxicity by Allium sativum extracts in Swiss albino mice.

Lead is a blue–gray and highly toxic divalent metal that occurs naturally in the earth's crust and is spread throughout the environment by various human activities. The efficacy of garlic (Allium

Amelioration of lead-induced hepatotoxicity by Allium sativum extracts in Swiss albino mice

Lead is a blue–gray and highly toxic divalent metal that occurs naturally in the earth's crust and is spread throughout the environment by various human activities. The efficacy of garlic (Allium

Developmental toxicity of metal chelating agents.

MiADMSA abrogates sodium tungstate-induced oxidative stress in rats

Preliminary results led us to conclude that sub-acute exposure to tungstate-induced oxidative stress could be effectively reduced by the administration of MiADMSA and thus might be a promising antidote for studying in detail its efficacy in reducing body tung State burden and its excretion post tung state exposure.

Altered Uptake and Biological Half-Lives of 65Zn on Arsenic Exposure—Modulation by Zinc Treatment

Zinc plays a significant role in regulating the biokinetics of 65Zn in the liver and the whole body of arsenic-intoxicated rats and the uptake values of 65 Zn were significantly increased in the Liver, brain, kidney, and intestine following arsenic treatment, and the values in the organs were decreased by zinc.



Monoisoamyl meso-2,3-dimercaptosuccinate: interaction with metallothionein-bound cadmium in vitro and evidence of active transport into renal and hepatic cells in vivo.

It was concluded that Mi-ADMS has a higher affinity for Cd in Cd-MT than does DMSA, and that the access of Mi- ADMS to intracellular Cd is, at least in part, mediated by the organic anion transport system.

Comparative effects of diethyldithiocarbamate, dimercaptosuccinate, and diethylenetriaminepentaacetate on organ distribution and excretion of cadmium.

It was concluded that the effectiveness of a chelator in promoting mobilization and excretion of metallothionein-bound Cd cannot be predicted on the basis of its effectiveness in protecting mice against a lethal dose of Cd when given immediately after Cd and prior to induction of meetallothionin synthesis.

meso-2,3-Dimercaptosuccinic acid: chemical, pharmacological and toxicological properties of an orally effective metal chelating agent.

Preclinical and clinical evidence now indicate that meso-2,3-dimercaptosuccinic acid, an Orphan Drug, shows the most promise for being effective in this regard, and has an extracellular distribution that may be responsible for its low toxicity compared to other dithiols.

Human studies with the chelating agents, DMPS and DMSA.

There was a positive correlation between the amount of mercury excreted and the amalgam score and DMPS might be useful for increasing the urinary excretion of mercury and thus increasing the significance and reliability of this measure of mercury exposure.

The influence of chelating agents on the distribution and biotransformation of methylmercuric chloride in rats.

  • F. Planas-Bohne
  • Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1981
Male albino rats were injected i.p. with [203Hg]methylmercuric chloride and later at different time intervals they received N-acetylpenicillamine, 2,3-dimercaptopropane-1-sulfonate or dimercaptosuccinic acid and DMSA, showing virtually 100% absorption of the chelating agent from the gastrointestinal tract.

Decreasing 203Hg retention by intraperitoneal treatment with monoalkyl esters of meso‐2,3‐dimercaptosuccinic acid in rats

The effect of nine monoalkyl esters of meso‐2,3‐dimercaptosuccinic acid (DMSA) on 203Hg retention after a single i.p. dose was evaluated in 6–7 week‐old female albino rats, with a significantly lower body burden of mercury than the controls.

Chronic lead poisoning treated with dimercaptosuccinic acid.

DMSA is an efficient chelator that results in a rapid, though temporary decrease in B-Pb, and although oral treatment with this chelator may be supervised from the out-patient clinic, careful monitoring for potential side effects is recommended.