Developmental toxicity assessment of thermoresponsive poly(N-isopropylacrylamide-co-acrylamide) oligomers in CD-1 mice.

@article{Ankareddi2008DevelopmentalTA,
  title={Developmental toxicity assessment of thermoresponsive poly(N-isopropylacrylamide-co-acrylamide) oligomers in CD-1 mice.},
  author={Induvadana Ankareddi and Melissa M. Bailey and Christopher S. Brazel and Jane F. Rasco and Ronald D. Hood},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2008},
  volume={83 2},
  pages={112-6}
}
BACKGROUND Although polymers and hydrogels are used successfully in biomedical applications, including implants and drug delivery devices, smaller molecular weight oligomers, such as those investigated here, have not been extensively studied in vivo. Poly(N-isopropylacrylamide-co-acrylamide), or P(NIPAAm-co-AAm), has a unique thermoresponsive behavior and is under investigation as a novel drug delivery system for metastatic cancer treatment. To date, no studies have been published regarding the… CONTINUE READING
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