Developmental toxicity and structure-activity relationships of chlorophenols using human embryonic palatal mesenchymal cells.

@article{Zhao1995DevelopmentalTA,
  title={Developmental toxicity and structure-activity relationships of chlorophenols using human embryonic palatal mesenchymal cells.},
  author={Feng R. Zhao and Kittane Mayura and Robert W. Hutchinson and R. P. Fischer Lewis and Robert C. Burghardt and Timothy D Phillips},
  journal={Toxicology letters},
  year={1995},
  volume={78 1},
  pages={
          35-42
        }
}
The chlorophenols (CPs) comprise a major class of widely distributed and frequently occurring environmental contaminants. Previous studies have demonstrated the adverse effects of CPs on embryonic and fetal development. HEPM (human embryonic palatal mesenchymal) and MOT (mouse ovarian tumor) cell lines have been utilized in complementary bioassays for the detection of teratogens, but not the CPs. In this study, our objectives were 2-fold: (1) to determine if the HEPM assay could be used to… CONTINUE READING
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