Developmental toxic potential of di-n-propyl phthalate administered orally to rats.

@article{Saillenfait2011DevelopmentalTP,
  title={Developmental toxic potential of di-n-propyl phthalate administered orally to rats.},
  author={Anne-Marie Saillenfait and alain-claude roudot and Fr{\'e}d{\'e}ric Gallissot and Jean-Philippe Sabat{\'e} and Miguel Chagnon},
  journal={Journal of applied toxicology : JAT},
  year={2011},
  volume={31 1},
  pages={
          36-44
        }
}
The objective of this study was to evaluate the developmental toxic potential of di-n-propyl phthalate (DnPP) in rats. Pregnant Sprague-Dawley rats were given DnPP at doses of 0 (olive oil), 0.5, 1 and 1.5 g kg⁻¹ per day, by gavage, on gestation days 6-20. Benchmark doses were calculated for the effects of DnPP on fetal weight and anogenital distance of the male fetuses. Maternal body weight gain was significantly reduced at 1.5 g kg⁻¹ per day, over gestation days 6-9. DnPP-treated dams also… CONTINUE READING
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