Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth.

@article{Kikuchi2006DevelopmentalSO,
  title={Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth.},
  author={Kazu Kikuchi and Motonari Kondo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 47},
  pages={17852-7}
}
Hematopoiesis originated by hematopoietic stem cells (HSCs) is distinguishable between fetal and adult mice. However, it is not clear whether the altered mode of differentiation is due to the change of properties of HSCs or different microenvironments in fetuses and adults. Here we show that fetal HSCs are fully capable of giving rise to all classes of B cells in the adult microenvironment. HSCs that are derived from fetal liver but not adult bone marrow (BM) of IL-7 receptor alpha chain (IL… CONTINUE READING
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Cell 121:295–306

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