Developmental switch in the relative expression of the alpha 1- and alpha 2-globin genes in humans and in transgenic mice.

@article{Albitar1992DevelopmentalSI,
  title={Developmental switch in the relative expression of the alpha 1- and alpha 2-globin genes in humans and in transgenic mice.},
  author={Maher Albitar and Faith E. Cash and Cesare Peschle and S. A. Liebhaber},
  journal={Blood},
  year={1992},
  volume={79 9},
  pages={2471-4}
}
Human alpha-globin is encoded by two adjacent genes, alpha 2 and alpha 1. Despite their remarkable level of structural identity, the more 5' (alpha 2) gene is the major alpha-globin locus in the normal adult, expressed at 2.6-fold higher levels than the adjacent and more 3' (alpha 1) globin gene. In light of the well-characterized pattern of gene activation in the human alpha- and beta-globin gene clusters during development, we considered the possibility that the relative expression of these… CONTINUE READING

From This Paper

Topics from this paper.
7 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…