Developmental stage specificity of the lymphoid V(D)J recombination activity.

  title={Developmental stage specificity of the lymphoid V(D)J recombination activity.},
  author={Michael R. Lieber and Joanne E Hesse and Kiyoshi Mizuuchi and Martin Gellert},
  journal={Genes & development},
  volume={1 8},
We have examined the level of immunoglobulin gene V(D)J recombination activity in a number of cell lines derived from lymphoid or nonlymphoid lineages. The assay we employed uses extrachromosomal DNA as substrate and thereby avoids difficulties associated with the use of chromosomally integrated substrates. The recombination activity decreases during B-lymphoid development. It is highest at the earliest stages of committed B-cell differentiation and then falls progressively, reaching… CONTINUE READING
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