Developmental stage-specific effects of perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on reproductive organs of male rat offspring.

@article{Ohsako2002DevelopmentalSE,
  title={Developmental stage-specific effects of perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on reproductive organs of male rat offspring.},
  author={Seiichiroh Ohsako and Yuichi Miyabara and Motoharu Sakaue and Ryuta Ishimura and Masaki Kakeyama and Hiroyuki Izumi and Junzo Yonemoto and Chiharu Tohyama},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2002},
  volume={66 2},
  pages={283-92}
}
Exposure to a relatively low dose of 2,3,7,8-tetrachlorodebenzo-p-dioxin (TCDD) during mid-gestation induces a reduction of ventral prostate weight in rat offspring. Recently we reported that a single administration of TCDD (12.5-800 ng/kg body weight) to pregnant Holtzman rats on gestational day (GD) 15 caused a decrease in androgen receptor (AR) mRNA level in the ventral prostate during the prepubertal period, and we proposed that this reduction of AR mRNA is one of the most sensitive adverse… CONTINUE READING

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