Developmental signaling: does it bridge the gap between cilia dysfunction and renal cystogenesis?

@article{Tran2014DevelopmentalSD,
  title={Developmental signaling: does it bridge the gap between cilia dysfunction and renal cystogenesis?},
  author={Pamela V Tran and Madhulika Sharma and Xiaogang Li and James P. Calvet},
  journal={Birth defects research. Part C, Embryo today : reviews},
  year={2014},
  volume={102 2},
  pages={159-73}
}
For more than a decade, evidence has accumulated linking dysfunction of primary cilia to renal cystogenesis, yet molecular mechanisms remain undefined. The pathogenesis of renal cysts is complex, involving multiple cellular aberrations and signaling pathways. Adding to this complexity, primary cilia exhibit multiple roles in a context-dependent manner. On renal epithelial cells, primary cilia act as mechanosensors and trigger extracellular Ca(2+) influx in response to laminar fluid flow. During… CONTINUE READING

From This Paper

Topics from this paper.

References

Publications referenced by this paper.
Showing 1-10 of 107 references

A causes cystic kidneys without mitotic spindle misorientation

  • CM Karner, R Chirumamilla, S Aoki
  • J Am Soc Nephrol
  • 2009
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…