Developmental roles of platelet-derived growth factors.

  title={Developmental roles of platelet-derived growth factors.},
  author={Christer Betsholtz and Linda Karlsson and Per Lindahl},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={23 6},
Platelet-derived growth factor (PDGF) was originally identified in platelets and in serum as a mitogen for fibroblasts, smooth muscle cells (SMC) and glia cells in culture. PDGF has since expanded to a family of dimers of at least four gene products, whose biological actions are mediated through two receptor tyrosine kinases, PDGFRs. The present review summarizes and discusses the biological functions of PDGFs and PDGFRs in developmental processes, mainly as revealed through genetic analysis in… CONTINUE READING