Developmental reprogramming of reproductive and metabolic dysfunction in sheep: native steroids vs. environmental steroid receptor modulators.

@article{Padmanabhan2010DevelopmentalRO,
  title={Developmental reprogramming of reproductive and metabolic dysfunction in sheep: native steroids vs. environmental steroid receptor modulators.},
  author={Vasantha Padmanabhan and H. Nandakumar Sarma and Mozhgan Savabieasfahani and Teresa L Steckler and Almudena Veiga-Lopez},
  journal={International journal of andrology},
  year={2010},
  volume={33 2},
  pages={394-404}
}
The inappropriate programming of developing organ systems by exposure to excess native or environmental steroids, particularly the contamination of our environment and our food sources with synthetic endocrine disrupting chemicals that can interact with steroid receptors, is a major concern. Studies with native steroids have found that in utero exposure of sheep to excess testosterone, an oestrogen precursor, results in low birth weight offspring and leads to an array of adult reproductive… CONTINUE READING
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