Developmental regulation of the alpha-glycerophosphate shuttle in porcine myocardium.

  title={Developmental regulation of the alpha-glycerophosphate shuttle in porcine myocardium.},
  author={Thomas D. Scholz and Stacia L Koppenhafer and Cynthia J Teneyck and Brian C. Schutte},
  journal={Journal of molecular and cellular cardiology},
  volume={29 6},
The alpha-glycerophosphate (alpha-GP) shuttle has been shown to play a role in reducing equivalent transfer in neonatal cardiac mitochondria. In adult heart mitochondria, alpha-GP shuttle activity is not detectable. The goals of the current study were to define the time course of the age-dependent decline in alpha-GP shuttle capacity and to identify the enzymatic step(s) of the alpha-GP shuttle which are regulated during development. Intact mitochondria were isolated from porcine hearts of… CONTINUE READING

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